BMP5

Across TCGA patient cohorts, BMP5 mutation is significantly associated with the RNA expression of many other genes, with 4,279 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP5-associated genes across cancer lineages are RANBP1, CRNKL1, and POLR3F. Each is linked with BMP5 in more than 3 cancer types. Because this analysis shows association rather than direction, both BMP5-to-partner and partner-to-BMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RANBP1 grouped by BMP5-low versus BMP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP5→partner) and Y-score (partner→BMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RANBP1 →	+0.516	+2.600	<.001	<.001	3	4
SKCM	CRNKL1 →	+0.380	+1.681	.001	.003	3	3
SKCM	POLR3F →	+0.417	+2.175	<.001	<.001	3	3
UCEC	PDCD2 →	+0.348	+2.545	<.001	<.001	3	3
LIHC	SNRPGP3 →	+0.186	+4.733	.002	.003	3	3
UCEC	VBP1 →	+0.509	+2.191	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,279 associations by consensus.

RANBP1 by BMP5 expression — UCEC

Explore this box plot interactively →