BMP5

Across TCGA patient cohorts, BMP5 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP5-associated genes across cancer lineages are C-Raf, Notch1, and p62 Lck ligand. Each is linked with BMP5 in more than 2 cancer types. Because this analysis shows association rather than direction, both BMP5-to-partner and partner-to-BMP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by BMP5-low versus BMP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP5→partner) and Y-score (partner→BMP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.127	+1.584	.011	.034	3	3
UCEC	Notch1 →	+0.135	+1.662	.006	.011	3	2
UCEC	p62 Lck ligand →	+0.339	+1.817	.003	.015	3	2
UCEC	Src_pY527 →	-0.307	-2.105	.043	.017	3	2
UCEC	Caspase-8 →	-0.225	-3.673	.011	.001	3	2
UCEC	CD49b →	-0.214	-2.308	.033	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

C-Raf by BMP5 expression — UCEC

Explore this box plot interactively →