BMP4

Across TCGA pan-cancer cohorts, BMP4 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated BMP4 data layer compared with 21 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher BMP4 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BMP4 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC and LSCC are the cancer types where BMP4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.484	1.000	.020	14	view →
LSCC	OS	Quartile	All	1.000	0.712	.005	5	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

BMP4–HNSC (OS)

Open the HNSC breakdown →