BMP4

Across TCGA patient cohorts, BMP4 protein abundance is significantly associated with the RNA expression of many other genes, with 3,501 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BMP4-associated genes across cancer lineages are RNU6-9, RNASET2, and SYNGR1. Each is linked with BMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP4-to-partner and partner-to-BMP4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BMP4 versus RNU6-9 in LSCC, with a Pearson correlation of 0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP4→partner) and Y-score (partner→BMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RNU6-9 →	+1.105	+0.719	.001	<.001	3	2
HNSC	RNASET2 →	+0.563	+1.059	.002	<.001	3	2
LSCC	SYNGR1 →	-0.665	-0.450	.002	.008	3	1
LSCC	KLC3 →	-0.982	-0.556	.003	.009	3	1
LSCC	DUSP3 →	-0.385	-0.457	.001	.005	3	1
LSCC	POU2AF1 →	+1.157	+0.543	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,501 associations by consensus.

BMP4 vs RNU6-9 — LSCC

Explore this scatter interactively →