BMP4

Across TCGA patient cohorts, BMP4 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP4-associated genes across cancer lineages are Annexin-1, Notch1, and PCNA. Each is linked with BMP4 in more than 2 cancer types. Because this analysis shows association rather than direction, both BMP4-to-partner and partner-to-BMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by BMP4-low versus BMP4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP4→partner) and Y-score (partner→BMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.532	+3.604	.004	.001	3	3
UCEC	Notch1 →	+0.187	+2.817	<.001	.001	3	2
UCEC	PCNA →	+0.184	+2.321	.018	.005	3	2
UCEC	EGFR_pY1068 →	-0.218	-2.222	.016	.010	3	1
UCEC	FoxM1 →	+0.185	+2.321	.047	.001	3	1
UCEC	INPP4B →	-0.297	-2.700	.010	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Annexin-1 by BMP4 expression — UCEC

Explore this box plot interactively →