BMP4

Across TCGA cell cohorts, BMP4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible BMP4-associated genes across cancer lineages are MMP27, BPIFB6, and OR6J1. Each is linked with BMP4 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP4-to-partner and partner-to-BMP4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MMP27 grouped by BMP4-low versus BMP4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP4→partner) and Y-score (partner→BMP4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	MMP27 →	+0.013	+3.969	<.001	.009	3	1
BLOOD_Leukemia	BPIFB6 →	+0.031	+3.969	<.001	.009	3	1
BLOOD_Leukemia	OR6J1 →	+0.034	+3.234	<.001	.008	3	1
BLOOD_Leukemia	GUCA2B →	+0.015	+3.969	<.001	.009	3	1
LUNG_SCLC	HSFY1 →	+0.146	+4.817	<.001	.001	3	1
LUNG_SCLC	PRAMEF10 →	+0.885	+4.643	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

MMP27 by BMP4 expression — BLOOD_Leukemia

Explore this box plot interactively →