Across TCGA pan-cancer cohorts, BMP2KL RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated BMP2KL data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher BMP2KL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated BMP2KL expression acts as an unfavorable survival marker, although some lineages such as LAML and BRCA show a favorable association.

BLCA, CHOL, and UVM are the cancer types where BMP2KL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Tertile	IV	0.331	0.512	.005	87	view →
CHOL	OS	Tertile	III,IV	0.024	0.772	.008	54	view →
UVM	DFS	Tertile	All	0.158	0.774	.003	42	view →
LAML	DFS	Tertile	All	0.647	0.324	.003	34	view →
BRCA	DFS	Tertile	III,IV	0.882	0.762	.011	26	view →
READ	DFS	Tertile	II,III,IV	0.229	0.667	.017	24	view →
STAD	OS	Quartile	II,III,IV	0.751	0.620	.019	20	view →
LUAD	DFS	Tertile	IV	0.047	0.565	<.001	18	view →
LGG	DFS	Tertile	All	0.290	0.451	.001	18	view →
ESCA	OS	Tertile	All	0.601	0.789	.008	14	view →
UCEC	OS	Tertile	III,IV	0.767	0.852	.019	14	view →
COAD	DFS	Tertile	II,III,IV	0.811	0.450	.016	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 15 lineages.

Exploration

Same gene, other analysis: BMP2KL tumor-vs-normal RNA expression · all BMP2KL data types