BMP2K

Across TCGA pan-cancer cohorts, BMP2K mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of BMP2K’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where BMP2K mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BMP2K is over-expressed in tumor, although a few such as LSCC and COAD show the opposite, repressed pattern.

CCRCC, PDAC, and LSCC are the cancer types where BMP2K tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BMP2K mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	All	+0.458	<.001	11	view →
PDAC	All	All	+0.323	<.001	6	view →
LSCC	Male	II,III,IV	−0.138	<.001	6	view →
COAD	Male	All	−0.156	.001	4	view →
OV	All	All	+0.176	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

BMP2K–CCRCC

Open the CCRCC breakdown →