BMP2K

Across TCGA patient cohorts, BMP2K mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP2K-associated genes across cancer lineages are JNK2, MSH6, and p90 RSK. Each is linked with BMP2K in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP2K-to-partner and partner-to-BMP2K results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by BMP2K-low versus BMP2K-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP2K→partner) and Y-score (partner→BMP2K) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.215	+2.115	<.001	<.001	3	2
UCEC	MSH6 →	-0.321	-2.222	.002	.009	3	2
UCEC	p90 RSK →	+0.139	+1.366	.020	.010	3	2
UCEC	PDCD4 →	-0.381	-1.700	.010	.040	3	2
UCEC	Caspase-8 →	-0.247	-2.710	.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.218	-1.137	.005	.041	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

JNK2 by BMP2K expression — UCEC

Explore this box plot interactively →