BMP2

Across TCGA patient cohorts, BMP2 mutation is significantly associated with the RNA expression of many other genes, with 2,432 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP2-associated genes across cancer lineages are TRIM58, TERT, and SLC4A2. Each is linked with BMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP2-to-partner and partner-to-BMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM58 grouped by BMP2-low versus BMP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP2→partner) and Y-score (partner→BMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM58 →	-0.428	-2.523	.009	<.001	3	2
UCEC	TERT →	+0.543	+1.839	<.001	.002	3	2
UCEC	SLC4A2 →	+0.536	+2.169	.001	<.001	3	2
UCEC	PPIH →	+0.321	+2.169	.008	<.001	3	2
UCEC	MLXIP →	+0.429	+1.850	.002	.002	3	2
UCEC	GATD1 →	+0.400	+2.447	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,432 associations by consensus.

TRIM58 by BMP2 expression — UCEC

Explore this box plot interactively →