BMP2

Across TCGA patient cohorts, BMP2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP2-associated genes across cancer lineages are TIGAR, Di-Ras3, and EGFR_pY1068. Each is linked with BMP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP2-to-partner and partner-to-BMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by BMP2-low versus BMP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP2→partner) and Y-score (partner→BMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.140	+1.441	.014	.029	3	2
UCEC	Di-Ras3 →	-0.133	-3.308	.016	.009	3	2
UCEC	EGFR_pY1068 →	-0.281	-3.459	.002	.005	3	1
UCEC	GATA6 →	-0.127	-1.700	.032	.042	3	1
UCEC	JNK2 →	+0.194	+2.662	.009	<.001	3	1
UCEC	Ku80 →	+0.212	+1.778	.016	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

TIGAR by BMP2 expression — UCEC

Explore this box plot interactively →