BMP2

Across TCGA cell cohorts, BMP2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,473 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible BMP2-associated GO terms across cancer lineages are Positive regulation of bone mineralization involved in bone maturation, Neuroendocrine cell differentiation, and Negative regulation of insulin-like growth factor receptor signaling pathway. Each is linked with BMP2 in more than 17 cancer types. Because this analysis shows association rather than direction, both BMP2-to-partner and partner-to-BMP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of bone mineralization involved in bone maturation grouped by BMP2-low versus BMP2-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP2→partner) and Y-score (partner→BMP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of bone mineralization involved in bone maturation →	+1.821	+3.264	<.001	<.001	3	18
OESOPHAGUS	Neuroendocrine cell differentiation →	-0.313	-1.537	<.001	<.001	3	17
OVARY	Negative regulation of insulin-like growth factor receptor signaling pathway →	-0.295	-1.063	<.001	<.001	3	11
LIVER	Positive regulation of phosphatase activity →	+1.077	+2.636	<.001	<.001	3	10
LIVER	Glandular epithelial cell differentiation →	+1.538	+2.582	<.001	<.001	3	10
SOFT_TISSUE	Regulation of phosphatase activity →	-0.128	-1.221	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,473 associations by consensus.

Positive regulation of bone mineralization involved in bone maturation by BMP2 expression — LIVER

Explore this box plot interactively →