BMP15

Across TCGA patient cohorts, BMP15 mutation is significantly associated with the RNA expression of many other genes, with 2,791 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP15-associated genes across cancer lineages are RNU6-765P, TUBB1P2, and NF1P10. Each is linked with BMP15 in more than 2 cancer types. Because this analysis shows association rather than direction, both BMP15-to-partner and partner-to-BMP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-765P grouped by BMP15-low versus BMP15-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP15→partner) and Y-score (partner→BMP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-765P →	+0.381	+7.731	<.001	.009	3	3
SKCM	TUBB1P2 →	+0.010	+4.163	<.001	.006	3	3
CESC	NF1P10 →	+0.115	+4.569	<.001	.005	3	2
GBM	RNU6-806P →	+0.647	+6.189	<.001	.001	3	2
GBM	KRTAP10-3 →	+0.091	+5.857	<.001	.002	3	2
GBM	TMEM184CP1 →	+0.068	+4.969	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,791 associations by consensus.

RNU6-765P by BMP15 expression — BRCA

Explore this box plot interactively →