BMP15

Across TCGA patient cohorts, BMP15 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMP15-associated genes across cancer lineages are PCNA, eIF4E, and JNK_pT183_Y185. Each is linked with BMP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP15-to-partner and partner-to-BMP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by BMP15-low versus BMP15-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP15→partner) and Y-score (partner→BMP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.207	+2.999	.017	.035	3	2
UCEC	eIF4E →	+0.227	+3.087	.007	<.001	3	1
UCEC	JNK_pT183_Y185 →	-0.153	-2.321	.024	.034	3	1
UCEC	MEK1 →	+0.535	+3.087	<.001	<.001	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.525	-2.700	.003	.006	3	1
UCEC	p62 Lck ligand →	+0.406	+2.125	.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

PCNA by BMP15 expression — UCEC

Explore this box plot interactively →