BMP15

Across TCGA cell cohorts, BMP15 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BMP15-associated genes across cancer lineages are UTF1, REG1B, and OR10W1. Each is linked with BMP15 in more than 1 cancer types. Because this analysis shows association rather than direction, both BMP15-to-partner and partner-to-BMP15 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UTF1 grouped by BMP15-low versus BMP15-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMP15→partner) and Y-score (partner→BMP15) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UTF1 →	+0.018	+3.632	<.001	.003	3	1
LARGE_INTESTINE	REG1B →	+3.374	+3.196	<.001	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.016	+3.977	<.001	.001	3	1
LUNG_SCLC	USP17L13 →	+0.013	+5.029	<.001	.006	3	1
LUNG_SCLC	USP17L17 →	+0.013	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

UTF1 by BMP15 expression — LARGE_INTESTINE

Explore this box plot interactively →