BMP1

Across TCGA pan-cancer cohorts, BMP1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated BMP1 data layer compared with 23 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher BMP1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated BMP1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

KICH, LUAD, and OV are the cancer types where BMP1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Median	All	0.025	0.904	<.001	36	view →
LUAD	OS	Median	All	0.257	0.795	<.001	19	view →
OV	DFS	Median	II,III,IV	0.255	0.542	.003	18	view →
UCEC	DFS	Median	All	0.956	0.611	.003	18	view →
SKCM	DFS	Median	II,III,IV	0.518	0.699	.008	13	view →
LIHC	OS	Median	All	0.031	0.777	<.001	12	view →
SARC	OS	Median	All	0.174	0.860	<.001	6	view →
BRCA	OS	Median	II,III,IV	0.116	0.564	.024	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
COAD	OS	Median	All	0.253	0.683	.042	2	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

BMP1–KICH (DFS)

Open the KICH breakdown →