BMP1

Across TCGA pan-cancer cohorts, BMP1 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated BMP1 data layer compared with 23 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BMP1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated BMP1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where BMP1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.708	0.878	<.001	78	view →
LUAD	OS	Tertile	All	0.665	0.868	.004	14	view →
CCRCC	DFS	Median	II,III,IV	0.204	0.806	.012	6	view →
GBM	OS	Tertile	All	0.691	0.938	.023	5	view →
UCEC	OS	Quartile	All	0.886	1.000	.038	2	view →
LSCC	OS	Tertile	All	0.736	1.000	.043	1	view →
HNSC	DFS	Tertile	II,III,IV	0.975	0.894	.047	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

BMP1–PDAC (DFS)

Open the PDAC breakdown →