BMF

Across TCGA patient cohorts, BMF mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BMF-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and JNK2. Each is linked with BMF in more than 1 cancer types. Because this analysis shows association rather than direction, both BMF-to-partner and partner-to-BMF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by BMF-low versus BMF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMF→partner) and Y-score (partner→BMF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.089	+2.000	.007	.032	3	2
UCEC	EGFR_pY1068 →	-0.226	-2.000	.046	.032	3	1
UCEC	JNK2 →	+0.258	+2.179	.003	.034	3	1
UCEC	Ku80 →	+0.328	+2.183	.002	.033	3	1
UCEC	mTOR_pS2448 →	-0.140	-2.000	.037	.032	3	1
UCEC	Notch1 →	+0.154	+2.700	.015	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

c-Met_pY1235 by BMF expression — UCEC

Explore this box plot interactively →