BMF

Across TCGA cell cohorts, BMF mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BMF-associated genes across cancer lineages are IQCF5 and CBLN4. Each is linked with BMF in more than 1 cancer types. Because this analysis shows association rather than direction, both BMF-to-partner and partner-to-BMF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IQCF5 grouped by BMF-low versus BMF-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BMF→partner) and Y-score (partner→BMF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IQCF5 →	+0.124	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CBLN4 →	+0.006	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

IQCF5 by BMF expression — BLOOD_Leukemia

Explore this box plot interactively →