BLVRA

Across TCGA patient cohorts, BLVRA mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLVRA-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Heregulin, and JNK2. Each is linked with BLVRA in more than 1 cancer types. Because this analysis shows association rather than direction, both BLVRA-to-partner and partner-to-BLVRA results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by BLVRA-low versus BLVRA-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLVRA→partner) and Y-score (partner→BLVRA) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.537	-2.571	.010	.011	3	2
UCEC	Heregulin →	-0.141	-3.156	.014	.018	3	1
UCEC	JNK2 →	+0.267	+2.584	.003	.011	3	1
UCEC	Ku80 →	+0.263	+1.887	.017	.031	3	1
UCEC	MEK1 →	+0.355	+3.169	.037	.019	3	1
UCEC	Myosin-IIa →	+0.204	+2.329	.028	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

p38-MAPK_pT180_Y182 by BLVRA expression — UCEC

Explore this box plot interactively →