BLOC1S6

Across TCGA pan-cancer cohorts, BLOC1S6 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BLOC1S6 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BLOC1S6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BLOC1S6 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, LUAD, and CCRCC are the cancer types where BLOC1S6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	II,III,IV	0.879	0.740	.011	7	view →
LUAD	DFS	Median	III,IV	0.286	0.678	.006	6	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.809	.031	3	view →
LSCC	OS	Median	II,III,IV	1.000	0.890	.037	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BLOC1S6–PDAC (DFS)

Open the PDAC breakdown →