BLOC1S6

Across TCGA pan-cancer cohorts, BLOC1S6 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of BLOC1S6’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where BLOC1S6 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BLOC1S6 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

COAD, CCRCC, and LUAD are the cancer types where BLOC1S6 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BLOC1S6 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	II,III,IV	+0.155	<.001	9	view →
CCRCC	Male	III,IV	+0.387	<.001	8	view →
LUAD	Female	All	+0.336	<.001	8	view →
LSCC	Male	All	+0.236	<.001	5	view →
PDAC	All	II,III,IV	−0.313	.009	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

BLOC1S6–COAD

Open the COAD breakdown →