BLOC1S6

Across TCGA patient cohorts, BLOC1S6 mutation is significantly associated with the RNA expression of many other genes, with 504 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLOC1S6-associated genes across cancer lineages are MIR7-2, VTRNA2-2P, and RNU6-874P. Each is linked with BLOC1S6 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLOC1S6-to-partner and partner-to-BLOC1S6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7-2 grouped by BLOC1S6-low versus BLOC1S6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S6→partner) and Y-score (partner→BLOC1S6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR7-2 →	+0.268	+3.206	<.001	.006	3	2
UCEC	VTRNA2-2P →	+0.549	+2.526	<.001	.007	3	2
BLCA	RNU6-874P →	+0.432	+5.329	.002	.006	3	2
UCEC	CRYBB2P1 →	+0.601	+3.343	.004	.005	3	1
UCEC	ATG4A →	+0.734	+3.218	<.001	.009	3	1
UCEC	MON1B →	+0.532	+3.375	.004	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 504 associations by consensus.

MIR7-2 by BLOC1S6 expression — UCEC

Explore this box plot interactively →