Across TCGA pan-cancer cohorts, BLOC1S3 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated BLOC1S3 data layer compared with 23 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher BLOC1S3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BLOC1S3 expression acts as an unfavorable survival marker.

LIHC and CHOL are the cancer types where BLOC1S3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.144	0.688	.013	9	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: BLOC1S3 tumor-vs-normal RNA expression · all BLOC1S3 data types