Across TCGA pan-cancer cohorts, BLOC1S3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BLOC1S3 data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher BLOC1S3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BLOC1S3 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, UCEC, and LUAD are the cancer types where BLOC1S3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.998	0.337	.004	28	view →
UCEC	OS	Median	II,III,IV	0.534	0.942	.006	22	view →
LUAD	DFS	Tertile	II,III,IV	0.300	0.781	.016	5	view →
LSCC	OS	Median	II,III,IV	1.000	0.907	.026	2	view →
CCRCC	DFS	Tertile	III,IV	1.000	0.826	.038	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: BLOC1S3 tumor-vs-normal RNA expression · all BLOC1S3 data types