Across TCGA patient cohorts, BLOC1S3 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLOC1S3-associated genes across cancer lineages are PDCD4, 4E-BP1, and PI3K-p85. Each is linked with BLOC1S3 in more than 1 cancer types. Because this analysis shows association rather than direction, both BLOC1S3-to-partner and partner-to-BLOC1S3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLOC1S3→partner) and Y-score (partner→BLOC1S3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.530	-3.321	.031	.010	3	2
UCEC	4E-BP1 →	+0.366	+3.321	.009	.010	3	1
UCEC	PI3K-p85 →	+0.271	+2.817	.013	.036	2	1
UCEC	VEGFR2 →	+0.393	+3.009	.011	.019	2	1
UCEC	A-Raf_pS299 →	-0.265	-3.321	<.001	.010	1	1
UCEC	Tuberin →	+0.398	+3.321	.004	.010	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

BLOC1S3 survival (RNA) · tumor vs normal (RNA) · all BLOC1S3 data types