Across TCGA pan-cancer cohorts, BLOC1S2 Mutation is linked to patient survival in 1 of 34 cancer types, making it a survival-associated BLOC1S2 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher BLOC1S2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BLOC1S2 expression acts as an unfavorable survival marker.

LUAD are the cancer types where BLOC1S2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.245	0.835	<.001	21	view →

Pink = unfavorable, green = favorable. Showing the 1 strongest of 1 lineages.

Exploration

Same gene, other analysis: BLOC1S2 tumor-vs-normal RNA expression · all BLOC1S2 data types