Across TCGA pan-cancer cohorts, BLOC1S2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BLOC1S2 data layer compared with 22 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BLOC1S2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BLOC1S2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, CCRCC, and LSCC are the cancer types where BLOC1S2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.966	0.751	.004	20	view →
CCRCC	OS	Median	III,IV	1.000	0.777	.005	12	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.203	.024	2	view →
HNSC	OS	Quartile	All	0.725	0.919	.046	1	view →
LUAD	DFS	Quartile	II,III,IV	0.612	0.987	.019	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: BLOC1S2 tumor-vs-normal RNA expression · all BLOC1S2 data types