Across TCGA pan-cancer cohorts, BLOC1S2 mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of BLOC1S2’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where BLOC1S2 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types BLOC1S2 is over-expressed in tumor, although a few such as HNSC and PDAC show the opposite, repressed pattern.

CCRCC, COAD, and HNSC are the cancer types where BLOC1S2 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in BLOC1S2 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+0.280	<.001	8	view →
COAD	Female	All	+0.186	<.001	6	view →
HNSC	Male	All	−0.121	.009	6	view →
PDAC	All	IV	−0.860	.026	2	view →
LUAD	Female	All	+0.119	.022	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: BLOC1S2 RNA expression & survival · all BLOC1S2 data types