BLOC1S1

Across TCGA pan-cancer cohorts, BLOC1S1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated BLOC1S1 data layer compared with 26 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BLOC1S1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated BLOC1S1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

UCEC, PDAC, and LSCC are the cancer types where BLOC1S1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	All	0.902	1.000	.006	44	view →
PDAC	DFS	Quartile	All	0.907	0.701	<.001	38	view →
LSCC	DFS	Quartile	II,III,IV	0.964	0.618	.007	11	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

BLOC1S1–UCEC (OS)

Open the UCEC breakdown →