BLMH

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, BLMH mutation is significantly associated with the RNA expression of many other genes, with 1,215 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLMH-associated genes across cancer lineages are RNU4-65P, RN7SL97P, and CDRT15P7. Each is linked with BLMH in more than 1 cancer types. Because this analysis shows association rather than direction, both BLMH-to-partner and partner-to-BLMH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-65P grouped by BLMH-low versus BLMH-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLMH→partner) and Y-score (partner→BLMH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
READRNU4-65P →+0.464+6.257<.001.00132
CESCRN7SL97P →+0.105+5.144.002.00332
CESCCDRT15P7 →+0.080+4.669<.001.00732
UCECATP6V1E1P2 →+0.172+2.077<.001.00332
SKCMMTND2P22 →+0.058+5.624<.001.00232
UCECRNA5SP405 →+0.259+2.997<.001.00632
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,215 associations by consensus.

RNU4-65P by BLMH expression — READ

Box plot of RNU4-65P in BLMH-low vs BLMH-high samples in READ.

Explore this box plot interactively →

Exploration