BLMH

Across TCGA patient cohorts, BLMH mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLMH-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and ACVRL1. Each is linked with BLMH in more than 1 cancer types. Because this analysis shows association rather than direction, both BLMH-to-partner and partner-to-BLMH results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by BLMH-low versus BLMH-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLMH→partner) and Y-score (partner→BLMH) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.120	-2.558	.002	.010	3	1
UCEC	EGFR_pY1068 →	-0.264	-1.906	.009	.016	3	1
UCEC	ACVRL1 →	-0.123	-2.986	.025	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-3.074	.002	<.001	3	1
UCEC	MSH2 →	-0.289	-1.848	.001	.049	3	1
UCEC	p62 Lck ligand →	+0.304	+2.415	.020	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by BLMH expression — UCEC

Explore this box plot interactively →