Across TCGA patient cohorts, BLM mutation is significantly associated with the RNA expression of many other genes, with 4,615 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLM-associated genes across cancer lineages are ESCO2, IGLC3, and RHBDD3. Each is linked with BLM in more than 2 cancer types. Because this analysis shows association rather than direction, both BLM-to-partner and partner-to-BLM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLM→partner) and Y-score (partner→BLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	ESCO2 →	+0.603	+2.604	.008	.006	3	3
SKCM	IGLC3 →	+2.532	+3.182	.006	.009	3	3
COAD	RHBDD3 →	+0.529	+3.348	<.001	.004	3	3
UCEC	DDX41 →	+0.276	+2.695	.002	<.001	3	3
UCEC	LONP1 →	+0.613	+1.698	<.001	<.001	3	3
UCEC	IGLV4-69 →	+1.191	+1.688	.006	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,615 associations by consensus.

Exploration

BLM survival (RNA) · tumor vs normal (RNA) · all BLM data types