Across TCGA patient cohorts, BLM mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BLM-associated genes across cancer lineages are ATM, Rad50, and FoxM1. Each is linked with BLM in more than 3 cancer types. Because this analysis shows association rather than direction, both BLM-to-partner and partner-to-BLM results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLM→partner) and Y-score (partner→BLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.409	-1.289	.004	.023	3	4
UCEC	Rad50 →	-0.163	-1.777	.035	.002	3	3
UCEC	FoxM1 →	+0.210	+1.523	.011	.008	3	2
UCEC	p27_pT198 →	+0.081	+2.807	.017	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.433	-1.764	.002	.002	3	2
UCEC	PCNA →	+0.296	+2.058	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

BLM survival (RNA) · tumor vs normal (RNA) · all BLM data types