Across TCGA cell cohorts, BLM RNA expression is significantly associated with the go_rna of many other GO terms, with 4,858 significant associations in total. BONE shows the largest number of these associations.

The most reproducible BLM-associated GO terms across cancer lineages are Formation of extrachromosomal circular DNA, Replication fork processing, and Telomere maintenance via semi-conservative replication. Each is linked with BLM in more than 19 cancer types. Because this analysis shows association rather than direction, both BLM-to-partner and partner-to-BLM results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BLM→partner) and Y-score (partner→BLM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Formation of extrachromosomal circular DNA →	+0.113	+0.907	<.001	.001	3	20
OESOPHAGUS	Replication fork processing →	+0.166	+1.406	<.001	.002	3	20
OESOPHAGUS	Telomere maintenance via semi-conservative replication →	+0.161	+1.676	<.001	<.001	3	20
BONE	Nuclear DNA replication →	+0.185	+1.047	<.001	<.001	3	20
OESOPHAGUS	Protein localization to kinetochore →	+0.223	+1.506	<.001	<.001	3	20
BONE	Cell cycle DNA replication →	+0.178	+1.047	<.001	<.001	3	20

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,858 associations by consensus.

Exploration

BLM survival (RNA) · tumor vs normal (RNA) · all BLM data types