BLK

Across TCGA pan-cancer cohorts, BLK Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BLK data layer compared with 25 for mass-spec protein.

The strongest signal is observed in breast invasive carcinoma (BRCA), where higher BLK Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated BLK expression acts as an unfavorable survival marker.

BRCA, LUSC, and HNSC are the cancer types where BLK Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BRCA	DFS	Median	All	0.132	0.528	<.001	14	view →
LUSC	OS	Median	All	0.361	0.823	.009	11	view →
HNSC	OS	Median	All	0.193	0.686	.005	9	view →
LGG	DFS	Median	All	0.174	0.731	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BLK–BRCA (DFS)

Open the BRCA breakdown →