Across TCGA cell cohorts, BLACE mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible BLACE-associated genes across cancer lineages are CCL8, FAM181A, and FCN2. Each is linked with BLACE in more than 1 cancer types. Because this analysis shows association rather than direction, both BLACE-to-partner and partner-to-BLACE results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BLACE→partner) and Y-score (partner→BLACE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CCL8 →	+0.042	+4.977	<.001	.007	3	1
LARGE_INTESTINE	FAM181A →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	FCN2 →	+0.052	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

BLACE survival (RNA) · tumor vs normal (RNA) · all BLACE data types