BIRC8

Across TCGA patient cohorts, BIRC8 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC8-associated genes across cancer lineages are GAPDH, EGFR_pY1068, and FoxM1. Each is linked with BIRC8 in more than 2 cancer types. Because this analysis shows association rather than direction, both BIRC8-to-partner and partner-to-BIRC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by BIRC8-low versus BIRC8-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC8→partner) and Y-score (partner→BIRC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	GAPDH →	+0.660	+3.000	.049	.036	3	3
UCEC	EGFR_pY1068 →	-0.231	-1.847	.003	.007	3	2
UCEC	FoxM1 →	+0.163	+1.137	.045	.041	3	2
UCEC	JNK_pT183_Y185 →	-0.159	-1.906	.002	.014	3	2
UCEC	p21 →	+0.147	+1.920	.015	.008	3	2
UCEC	Shc_pY317 →	-0.180	-2.662	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

GAPDH by BIRC8 expression — SKCM

Explore this box plot interactively →