BIRC8

Across TCGA cell cohorts, BIRC8 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible BIRC8-associated genes across cancer lineages are GALNTL5, F9, and TMIGD1. Each is linked with BIRC8 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC8-to-partner and partner-to-BIRC8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALNTL5 grouped by BIRC8-low versus BIRC8-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC8→partner) and Y-score (partner→BIRC8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	GALNTL5 →	+0.037	+4.087	<.001	.009	3	1
LUNG_SCLC	F9 →	+0.036	+5.643	<.001	.002	3	1
LUNG_SCLC	TMIGD1 →	+0.099	+5.029	<.001	.006	3	1
LUNG_SCLC	FFAR3 →	+0.058	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GALNTL5 by BIRC8 expression — URINARY_TRACT

Explore this box plot interactively →