BIRC7

Across TCGA patient cohorts, BIRC7 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC7-associated genes across cancer lineages are eIF4E, JNK2, and Ku80. Each is linked with BIRC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC7-to-partner and partner-to-BIRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by BIRC7-low versus BIRC7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC7→partner) and Y-score (partner→BIRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.207	+2.459	.042	.020	3	1
UCEC	JNK2 →	+0.328	+2.817	<.001	.036	3	1
UCEC	Ku80 →	+0.271	+2.335	.017	.018	3	1
UCEC	MEK1 →	+0.394	+3.169	.025	.019	3	1
UCEC	p62 Lck ligand →	+0.470	+3.179	.002	.010	3	1
UCEC	PDK1_pS241 →	+0.174	+3.000	.035	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

eIF4E by BIRC7 expression — UCEC

Explore this box plot interactively →