BIRC7

Across TCGA cell cohorts, BIRC7 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible BIRC7-associated genes across cancer lineages are OR10W1, SIGLECL1, and LRRC74A. Each is linked with BIRC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC7-to-partner and partner-to-BIRC7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by BIRC7-low versus BIRC7-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC7→partner) and Y-score (partner→BIRC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.022	+4.977	<.001	.007	3	1
LARGE_INTESTINE	SIGLECL1 →	+0.022	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	LRRC74A →	+0.008	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	TSHB →	+0.058	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	SLC22A8 →	+0.017	+3.628	<.001	.002	3	1
LUNG_NSCLC_LUAD	TENT5D →	+0.078	+3.614	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR10W1 by BIRC7 expression — LARGE_INTESTINE

Explore this box plot interactively →