BIRC6

Across TCGA pan-cancer cohorts, BIRC6 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated BIRC6 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BIRC6 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated BIRC6 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, PCPG, and ESCA are the cancer types where BIRC6 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.804	0.615	<.001	36	view →
PCPG	OS	Median	All	0.009	0.946	<.001	12	view →
ESCA	OS	Median	II,III,IV	0.103	0.868	<.001	12	view →
LUSC	DFS	Median	III,IV	0.883	0.501	.025	11	view →
LIHC	DFS	Median	II,III,IV	0.093	0.420	.005	8	view →
CHOL	OS	Median	III,IV	0.275	0.886	.045	6	view →
SKCM	OS	Median	II,III,IV	0.947	0.825	.020	5	view →
BLCA	OS	Median	II,III,IV	0.614	0.401	.029	4	view →
KIRP	OS	Median	III,IV	0.188	0.688	.049	3	view →
GBM	OS	Median	All	0.075	0.416	.011	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

BIRC6–UCEC (DFS)

Open the UCEC breakdown →