BIRC6

Across TCGA pan-cancer cohorts, BIRC6 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated BIRC6 data layer compared with 26 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher BIRC6 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BIRC6 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, PDAC, and LSCC are the cancer types where BIRC6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	All	1.000	0.887	.022	18	view →
PDAC	OS	Median	III,IV	0.451	0.963	.006	14	view →
LSCC	DFS	Quartile	II,III,IV	1.000	0.794	.020	13	view →
UCEC	OS	Quartile	II,III,IV	1.000	0.519	.027	8	view →
HNSC	DFS	Median	III,IV	0.939	1.000	.043	1	view →
CCRCC	DFS	Quartile	III,IV	0.391	0.682	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

BIRC6–COAD (DFS)

Open the COAD breakdown →