BIRC5

Across TCGA pan-cancer cohorts, BIRC5 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BIRC5 data layer compared with 31 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BIRC5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BIRC5 expression acts as an unfavorable survival marker, although some lineages such as LSCC and HNSC show a favorable association.

LSCC, HNSC, and GBM are the cancer types where BIRC5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	All	0.884	0.305	.002	12	view →
HNSC	OS	Median	III,IV	0.918	0.757	.013	8	view →
GBM	DFS	Tertile	All	0.817	0.347	.024	3	view →
LUAD	DFS	Quartile	II,III,IV	0.932	0.578	.041	1	view →
PDAC	DFS	Median	II,III,IV	1.000	0.815	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BIRC5–LSCC (DFS)

Open the LSCC breakdown →