BIRC5

Across TCGA patient cohorts, BIRC5 protein abundance is significantly associated with the RNA expression of many other genes, with 16,737 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible BIRC5-associated genes across cancer lineages are CDCA8, HJURP, and TROAP. Each is linked with BIRC5 in more than 6 cancer types. Because this analysis shows association rather than direction, both BIRC5-to-partner and partner-to-BIRC5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, BIRC5 versus CDCA8 in OV, with a Pearson correlation of 0.83.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC5→partner) and Y-score (partner→BIRC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CDCA8 →	+1.478	+0.843	.006	.003	3	7
OV	HJURP →	+1.824	+0.526	.003	.007	3	6
OV	TROAP →	+2.096	+1.256	.001	.003	3	6
OV	CCNF →	+1.203	+1.171	.007	.008	3	6
LUAD	TPX2 →	+1.760	+0.777	<.001	<.001	3	6
OV	CLSPN →	+1.610	+0.843	<.001	.003	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,737 associations by consensus.

BIRC5 vs CDCA8 — OV

Explore this scatter interactively →