BIRC5

Across TCGA patient cohorts, BIRC5 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible BIRC5-associated genes across cancer lineages are JNK2, Myosin-IIa, and Tuberin. Each is linked with BIRC5 in more than 1 cancer types. Because this analysis shows association rather than direction, both BIRC5-to-partner and partner-to-BIRC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by BIRC5-low versus BIRC5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC5→partner) and Y-score (partner→BIRC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.362	+3.026	<.001	.018	3	1
UCEC	Myosin-IIa →	+0.292	+2.818	.002	.035	3	1
UCEC	Tuberin →	+0.394	+2.817	.005	.036	3	1
UCEC	VHL →	-1.314	-3.169	<.001	.019	3	1
UCEC	Caspase-8 →	-0.300	-3.321	.023	.010	3	1
UCEC	ATM →	-0.531	-3.321	.025	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

JNK2 by BIRC5 expression — UCEC

Explore this box plot interactively →