BIRC5

Across TCGA cell cohorts, BIRC5 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,536 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible BIRC5-associated GO terms across cancer lineages are Nuclear division, Positive regulation of cell cycle process, and Nuclear chromosome segregation. Each is linked with BIRC5 in more than 19 cancer types. Because this analysis shows association rather than direction, both BIRC5-to-partner and partner-to-BIRC5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Nuclear division grouped by BIRC5-low versus BIRC5-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (BIRC5→partner) and Y-score (partner→BIRC5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Nuclear division →	+0.129	+1.528	<.001	<.001	3	20
STOMACH	Positive regulation of cell cycle process →	+0.101	+1.175	<.001	<.001	3	20
OESOPHAGUS	Nuclear chromosome segregation →	+0.153	+1.437	<.001	.001	3	19
BONE	Positive regulation of nuclear cell cycle DNA replication →	+0.198	+1.472	<.001	.009	3	19
UPPER_AERODIGESTIVE_TRACT	Negative regulation of cell cycle process →	+0.069	+1.316	.001	<.001	3	19
OESOPHAGUS	Microtubule cytoskeleton organization involved in mitosis →	+0.121	+1.120	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,536 associations by consensus.

Nuclear division by BIRC5 expression — OESOPHAGUS

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