BIRC3

Across TCGA pan-cancer cohorts, BIRC3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BIRC3 data layer compared with 26 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher BIRC3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated BIRC3 expression acts as an unfavorable survival marker.

THYM, LUAD, and PRAD are the cancer types where BIRC3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	All	0.039	0.928	<.001	24	view →
LUAD	DFS	Median	IV	0.342	0.893	<.001	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
HNSC	OS	Median	III,IV	0.086	0.674	.004	6	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BIRC3–THYM (OS)

Open the THYM breakdown →