BIRC3

Across TCGA pan-cancer cohorts, BIRC3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated BIRC3 data layer compared with 26 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher BIRC3 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated BIRC3 expression acts as an unfavorable survival marker, although some lineages such as LSCC and UCEC show a favorable association.

LSCC, UCEC, and CCRCC are the cancer types where BIRC3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	All	1.000	0.296	.017	4	view →
UCEC	DFS	Median	All	1.000	0.734	.047	4	view →
CCRCC	OS	Median	III,IV	0.737	0.285	.023	3	view →
LUAD	DFS	Tertile	III,IV	1.000	0.600	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

BIRC3–LSCC (DFS)

Open the LSCC breakdown →