BIRC2

Across TCGA pan-cancer cohorts, BIRC2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated BIRC2 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher BIRC2 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated BIRC2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and CCRCC show a favorable association.

UCEC, GBM, and CCRCC are the cancer types where BIRC2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Median	II,III,IV	1.000	0.620	.011	38	view →
GBM	DFS	Tertile	All	0.183	0.369	.002	25	view →
CCRCC	DFS	Median	All	0.850	0.600	.025	6	view →
LUAD	OS	Tertile	All	0.999	0.918	.041	1	view →
PDAC	OS	Tertile	III,IV	0.621	1.000	.049	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

BIRC2–UCEC (OS)

Open the UCEC breakdown →